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| Unknown | 1992-06-06 | 162.1 KB |
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| OS/2 Installation Package (archive/os2InstallPackage)
| ext
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|00002870| 63 6f 6d 65 64 6f 6e 65 | 73 2e 2d 2d 50 2e 45 2e |comedone|s.--P.E.|
|00002880| 20 50 6f 63 68 69 2c 20 | 4d 2e 44 2e 0d 0a 24 55 | Pochi, |M.D...$U|
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|000028a0| 33 7d 0d 0a 24 54 69 74 | 6c 65 7b 55 73 65 20 6f |3}..$Tit|le{Use o|
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|000028e0| 0d 0a 24 41 75 74 68 6f | 72 7b 52 6f 74 68 6d 61 |..$Autho|r{Rothma|
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|00002910| 42 6f 73 74 6f 6e 20 55 | 6e 69 76 7d 0d 0a 24 53 |Boston U|niv}..$S|
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|00002990| 4a 6f 75 72 6e 61 6c 7b | 4a 20 41 6d 20 41 63 61 |Journal{|J Am Aca|
|000029a0| 64 20 44 65 72 6d 61 74 | 6f 6c 7d 0d 0a 24 56 6f |d Dermat|ol}..$Vo|
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|000029c0| 34 33 31 2d 34 34 32 7d | 0d 0a 24 44 61 74 65 7b |431-442}|..$Date{|
|000029d0| 53 65 70 74 65 6d 62 65 | 72 20 31 39 38 38 7d 0d |Septembe|r 1988}.|
|000029e0| 0a 24 59 42 56 6f 6c 7b | 31 39 38 39 20 59 65 61 |.$YBVol{|1989 Yea|
|000029f0| 72 20 42 6f 6f 6b 20 6f | 66 20 44 65 72 6d 61 74 |r Book o|f Dermat|
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|00002a10| 7b 31 2d 34 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |{1-4}..$|YBEditor|
|00002a20| 7b 44 72 73 2e 20 53 6f | 62 65 72 20 61 6e 64 20 |{Drs. So|ber and |
|00002a30| 46 69 74 7a 70 61 74 72 | 69 63 6b 7d 0d 0a 24 54 |Fitzpatr|ick}..$T|
|00002a40| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00002a50| 61 74 6f 72 7b 50 2e 45 | 2e 20 50 6f 63 68 69 2c |ator{P.E|. Pochi,|
|00002a60| 20 4d 2e 44 2e 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 | M.D.}..|..Copyri|
|00002a70| 67 68 74 20 28 63 29 20 | 59 65 61 72 20 42 6f 6f |ght (c) |Year Boo|
|00002a80| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|00002a90| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 38 39 |hers, In|c., 1989|
|00002aa0| 0d 0a 0d 0a 31 39 38 39 | 20 59 65 61 72 20 42 6f |....1989| Year Bo|
|00002ab0| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|00002ac0| 79 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |y (R)...|.Chapter|
|00002ad0| 20 31 2d 2d 41 63 6e 65 | 20 61 6e 64 20 52 65 6c | 1--Acne| and Rel|
|00002ae0| 61 74 65 64 20 44 69 73 | 6f 72 64 65 72 73 0d 0a |ated Dis|orders..|
|00002af0| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00002b00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b40| 2d 2d 0d 0a 55 73 65 20 | 6f 66 20 4f 72 61 6c 20 |--..Use |of Oral |
|00002b50| 61 6e 64 20 54 6f 70 69 | 63 61 6c 20 41 67 65 6e |and Topi|cal Agen|
|00002b60| 74 73 20 66 6f 72 20 41 | 63 6e 65 20 69 6e 20 50 |ts for A|cne in P|
|00002b70| 72 65 67 6e 61 6e 63 79 | 0d 0a 0d 0a 52 6f 74 68 |regnancy|....Roth|
|00002b80| 6d 61 6e 20 4b 46 3b 20 | 50 6f 63 68 69 20 50 45 |man KF; |Pochi PE|
|00002b90| 0d 0a 28 42 6f 73 74 6f | 6e 20 55 6e 69 76 29 0d |..(Bosto|n Univ).|
|00002ba0| 0a 4a 20 41 6d 20 41 63 | 61 64 20 44 65 72 6d 61 |.J Am Ac|ad Derma|
|00002bb0| 74 6f 6c 20 31 39 3a 34 | 33 31 2d 34 34 32 2c 20 |tol 19:4|31-442, |
|00002bc0| 53 65 70 74 65 6d 62 65 | 72 20 31 39 38 38 0d 0a |Septembe|r 1988..|
|00002bd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002be0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002bf0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002c00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002c10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002c20| 0d 0a 0d 0a 41 62 73 74 | 72 61 63 74 0d 0a 0d 0a |....Abst|ract....|
|00002c30| 20 20 20 20 20 44 65 72 | 6d 61 74 6f 6c 6f 67 69 | Der|matologi|
|00002c40| 73 74 73 20 61 72 65 20 | 6f 66 74 65 6e 20 63 6f |sts are |often co|
|00002c50| 6e 73 75 6c 74 65 64 20 | 62 79 20 70 72 65 67 6e |nsulted |by pregn|
|00002c60| 61 6e 74 20 77 6f 6d 65 | 6e 20 6f 72 20 77 6f 6d |ant wome|n or wom|
|00002c70| 65 6e 20 6f 66 0d 0a 63 | 68 69 6c 64 62 65 61 72 |en of..c|hildbear|
|00002c80| 69 6e 67 20 61 67 65 20 | 63 6f 6e 63 65 72 6e 69 |ing age |concerni|
|00002c90| 6e 67 20 61 63 6e 65 20 | 74 72 65 61 74 6d 65 6e |ng acne |treatmen|
|00002ca0| 74 2e 20 20 42 65 63 61 | 75 73 65 20 6f 66 20 61 |t. Beca|use of a|
|00002cb0| 20 6c 61 63 6b 20 6f 66 | 20 70 75 62 6c 69 73 68 | lack of| publish|
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|00002cd0| 20 73 61 66 65 74 79 20 | 6f 66 20 74 72 65 61 74 | safety |of treat|
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|00002dd0| 2e 0d 0a 20 20 20 20 20 | 4f 72 61 6c 20 66 6f 72 |... |Oral for|
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|00002e30| 6f 75 73 20 74 6f 6f 74 | 68 20 73 74 61 69 6e 69 |ous toot|h staini|
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|00002e50| 2e 20 20 4f 63 63 61 73 | 69 6f 6e 61 6c 6c 79 2c |. Occas|ionally,|
|00002e60| 20 74 65 74 72 61 63 79 | 63 6c 69 6e 65 0d 0a 68 | tetracy|cline..h|
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|00002f40| 68 72 6f 6d 79 63 69 6e | 20 61 70 70 65 61 72 73 |hromycin| appears|
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|00002f70| 73 20 68 61 76 65 20 6e | 65 76 65 72 20 62 65 65 |s have n|ever bee|
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|00002f90| 61 20 63 61 75 73 65 20 | 6f 66 20 66 65 74 61 6c |a cause |of fetal|
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|00002fb0| 6f 73 74 2d 43 6f 6d 6d | 65 6e 74 0d 0a 0d 0a 20 |ost-Comm|ent.... |
|00002fc0| 20 20 20 20 54 68 69 73 | 20 61 72 74 69 63 6c 65 | This| article|
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|00002ff0| 6f 6e 20 74 68 65 20 72 | 69 73 6b 73 20 6f 66 20 |on the r|isks of |
|00003000| 74 68 65 20 75 73 65 20 | 6f 66 0d 0a 64 72 75 67 |the use |of..drug|
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|00003020| 63 61 6c 2c 20 66 6f 72 | 20 74 68 65 20 74 72 65 |cal, for| the tre|
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|00003040| 6e 20 70 72 65 67 6e 61 | 6e 63 79 2c 20 62 6f 74 |n pregna|ncy, bot|
|00003050| 68 20 61 73 20 74 68 65 | 79 0d 0a 61 66 66 65 63 |h as the|y..affec|
|00003060| 74 20 74 68 65 20 6d 6f | 74 68 65 72 20 61 6e 64 |t the mo|ther and|
|00003070| 20 74 68 65 20 66 65 74 | 75 73 2e 20 20 45 78 63 | the fet|us. Exc|
|00003080| 65 70 74 20 66 6f 72 20 | 6f 72 61 6c 20 74 65 74 |ept for |oral tet|
|00003090| 72 61 63 79 63 6c 69 6e | 65 20 62 65 79 6f 6e 64 |racyclin|e beyond|
|000030a0| 20 74 68 65 20 66 69 72 | 73 74 0d 0a 74 72 69 6d | the fir|st..trim|
|000030b0| 65 73 74 65 72 20 61 6e | 64 2c 20 6f 66 20 63 6f |ester an|d, of co|
|000030c0| 75 72 73 65 2c 20 66 6f | 72 20 6f 72 61 6c 20 69 |urse, fo|r oral i|
|000030d0| 73 6f 74 72 65 74 69 6e | 6f 69 6e 2c 20 6d 6f 73 |sotretin|oin, mos|
|000030e0| 74 20 6d 65 64 69 63 61 | 74 69 6f 6e 73 20 61 72 |t medica|tions ar|
|000030f0| 65 20 73 61 66 65 20 74 | 6f 0d 0a 75 73 65 2c 20 |e safe t|o..use, |
|00003100| 61 6c 74 68 6f 75 67 68 | 20 74 68 65 72 65 20 68 |although| there h|
|00003110| 61 73 20 62 65 65 6e 20 | 61 6e 20 69 6e 63 72 65 |as been |an incre|
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|00003140| 27 73 20 61 6e 64 20 74 | 68 65 0d 0a 70 68 79 73 |'s and t|he..phys|
|00003150| 69 63 69 61 6e 73 27 20 | 70 61 72 74 2c 20 61 62 |icians' |part, ab|
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|00003170| 72 75 67 73 20 69 6e 20 | 70 72 65 67 6e 61 6e 63 |rugs in |pregnanc|
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|00003200| 63 69 61 6e 20 74 6f 20 | 70 72 65 73 63 72 69 62 |cian to |prescrib|
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|00003230| 0a 74 72 65 61 74 6d 65 | 6e 74 2e 2d 2d 50 2e 45 |.treatme|nt.--P.E|
|00003240| 2e 20 50 6f 63 68 69 2c | 20 4d 2e 44 2e 0d 0a 24 |. Pochi,| M.D...$|
|00003250| 55 6e 69 71 75 65 5f 49 | 44 7b 59 52 42 30 34 37 |Unique_I|D{YRB047|
|00003260| 35 34 7d 0d 0a 24 54 69 | 74 6c 65 7b 41 20 43 6f |54}..$Ti|tle{A Co|
|00003270| 6d 70 61 72 69 73 6f 6e | 20 6f 66 20 44 6f 78 79 |mparison| of Doxy|
|00003280| 63 79 63 6c 69 6e 65 20 | 61 6e 64 20 4d 69 6e 6f |cycline |and Mino|
|00003290| 63 79 63 6c 69 6e 65 20 | 69 6e 20 74 68 65 20 54 |cycline |in the T|
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|000032b0| 20 56 75 6c 67 61 72 69 | 73 7d 0d 0a 24 41 75 74 | Vulgari|s}..$Aut|
|000032c0| 68 6f 72 7b 48 61 72 72 | 69 73 6f 6e 2c 20 50 56 |hor{Harr|ison, PV|
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|000032e0| 42 65 61 75 6d 6f 6e 74 | 20 48 6f 73 70 2c 20 4c |Beaumont| Hosp, L|
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|00003330| 63 79 63 6c 69 6e 65 20 | 69 6e 20 61 63 6e 65 20 |cycline |in acne |
|00003340| 76 75 6c 67 61 72 69 73 | 3b 0d 0a 41 63 6e 65 20 |vulgaris|;..Acne |
|00003350| 76 75 6c 67 61 72 69 73 | 20 6d 69 6e 6f 63 79 63 |vulgaris| minocyc|
|00003360| 6c 69 6e 65 20 69 6e 3b | 0d 0a 41 63 6e 65 20 76 |line in;|..Acne v|
|00003370| 75 6c 67 61 72 69 73 20 | 64 6f 78 79 63 79 63 6c |ulgaris |doxycycl|
|00003380| 69 6e 65 20 69 6e 7d 0d | 0a 24 4a 6f 75 72 6e 61 |ine in}.|.$Journa|
|00003390| 6c 7b 43 6c 69 6e 20 45 | 78 70 20 44 65 72 6d 61 |l{Clin E|xp Derma|
|000033a0| 74 6f 6c 7d 0d 0a 24 56 | 6f 6c 75 6d 65 7b 31 33 |tol}..$V|olume{13|
|000033b0| 7d 0d 0a 24 50 61 67 65 | 7b 32 34 32 2d 32 34 34 |}..$Page|{242-244|
|000033c0| 7d 0d 0a 24 44 61 74 65 | 7b 4a 75 6c 79 20 31 39 |}..$Date|{July 19|
|000033d0| 38 38 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |88}..$YB|Vol{1989|
|000033e0| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 44 65 | Year Bo|ok of De|
|000033f0| 72 6d 61 74 6f 6c 6f 67 | 79 7d 0d 0a 24 43 68 61 |rmatolog|y}..$Cha|
|00003400| 70 74 65 72 7b 31 2d 35 | 7d 0d 0a 24 59 42 45 64 |pter{1-5|}..$YBEd|
|00003410| 69 74 6f 72 7b 44 72 73 | 2e 20 53 6f 62 65 72 20 |itor{Drs|. Sober |
|00003420| 61 6e 64 20 46 69 74 7a | 70 61 74 72 69 63 6b 7d |and Fitz|patrick}|
|00003430| 0d 0a 24 54 61 62 6c 65 | 7b 7d 0d 0a 24 43 6f 6d |..$Table|{}..$Com|
|00003440| 6d 65 6e 74 61 74 6f 72 | 7b 50 2e 45 2e 20 50 6f |mentator|{P.E. Po|
|00003450| 63 68 69 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |chi, M.D|.}....Co|
|00003460| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
|00003470| 20 42 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 | Book Me|dical Pu|
|00003480| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 2c 20 |blishers|, Inc., |
|00003490| 31 39 38 39 0d 0a 0d 0a | 31 39 38 39 20 59 65 61 |1989....|1989 Yea|
|000034a0| 72 20 42 6f 6f 6b 20 6f | 66 20 44 65 72 6d 61 74 |r Book o|f Dermat|
|000034b0| 6f 6c 6f 67 79 20 28 52 | 29 0d 0a 0d 0a 43 68 61 |ology (R|)....Cha|
|000034c0| 70 74 65 72 20 31 2d 2d | 41 63 6e 65 20 61 6e 64 |pter 1--|Acne and|
|000034d0| 20 52 65 6c 61 74 65 64 | 20 44 69 73 6f 72 64 65 | Related| Disorde|
|000034e0| 72 73 0d 0a 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |rs....--|--------|
|000034f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003500| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003510| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003530| 2d 2d 2d 2d 2d 2d 0d 0a | 41 20 43 6f 6d 70 61 72 |------..|A Compar|
|00003540| 69 73 6f 6e 20 6f 66 20 | 44 6f 78 79 63 79 63 6c |ison of |Doxycycl|
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|00003560| 69 6e 65 20 69 6e 20 74 | 68 65 20 54 72 65 61 74 |ine in t|he Treat|
|00003570| 6d 65 6e 74 20 6f 66 20 | 41 63 6e 65 20 56 75 6c |ment of |Acne Vul|
|00003580| 67 61 72 69 73 0d 0a 0d | 0a 48 61 72 72 69 73 6f |garis...|.Harriso|
|00003590| 6e 20 50 56 0d 0a 28 42 | 65 61 75 6d 6f 6e 74 20 |n PV..(B|eaumont |
|000035a0| 48 6f 73 70 2c 20 4c 61 | 6e 63 61 73 74 65 72 2c |Hosp, La|ncaster,|
|000035b0| 20 45 6e 67 6c 61 6e 64 | 29 0d 0a 43 6c 69 6e 20 | England|)..Clin |
|000035c0| 45 78 70 20 44 65 72 6d | 61 74 6f 6c 20 31 33 3a |Exp Derm|atol 13:|
|000035d0| 32 34 32 2d 32 34 34 2c | 20 4a 75 6c 79 20 31 39 |242-244,| July 19|
|000035e0| 38 38 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |88..----|--------|
|000035f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003600| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003610| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003630| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00003640| 0d 0a 0d 0a 20 20 20 20 | 20 49 6e 20 61 20 31 32 |.... | In a 12|
|00003650| 2d 77 65 65 6b 2c 20 6f | 62 73 65 72 76 65 72 2d |-week, o|bserver-|
|00003660| 62 6c 69 6e 64 20 73 74 | 75 64 79 2c 20 74 68 65 |blind st|udy, the|
|00003670| 20 65 66 66 69 63 61 63 | 79 20 61 6e 64 20 74 6f | efficac|y and to|
|00003680| 6c 65 72 61 6e 63 65 20 | 6f 66 0d 0a 64 6f 78 79 |lerance |of..doxy|
|00003690| 63 79 63 6c 69 6e 65 2c | 20 35 30 20 6d 67 20 64 |cycline,| 50 mg d|
|000036a0| 61 69 6c 79 2c 20 77 61 | 73 20 63 6f 6d 70 61 72 |aily, wa|s compar|
|000036b0| 65 64 20 77 69 74 68 20 | 74 68 6f 73 65 20 6f 66 |ed with |those of|
|000036c0| 20 6d 69 6e 6f 63 79 63 | 6c 69 6e 65 2c 20 35 30 | minocyc|line, 50|
|000036d0| 20 6d 67 20 74 77 69 63 | 65 0d 0a 64 61 69 6c 79 | mg twic|e..daily|
|000036e0| 2c 20 69 6e 20 74 68 65 | 20 74 72 65 61 74 6d 65 |, in the| treatme|
|000036f0| 6e 74 20 6f 66 20 61 63 | 6e 65 20 76 75 6c 67 61 |nt of ac|ne vulga|
|00003700| 72 69 73 20 69 6e 20 34 | 33 20 70 61 74 69 65 6e |ris in 4|3 patien|
|00003710| 74 73 2e 20 20 41 73 73 | 65 73 73 6d 65 6e 74 20 |ts. Ass|essment |
|00003720| 77 61 73 20 6d 61 64 65 | 20 62 79 0d 0a 63 6f 75 |was made| by..cou|
|00003730| 6e 74 69 6e 67 20 74 68 | 65 20 6e 75 6d 62 65 72 |nting th|e number|
|00003740| 20 6f 66 20 63 79 73 74 | 73 2c 20 6e 6f 64 75 6c | of cyst|s, nodul|
|00003750| 65 73 2c 20 70 75 73 74 | 75 6c 65 73 2c 20 61 6e |es, pust|ules, an|
|00003760| 64 20 70 61 70 75 6c 65 | 73 20 6f 6e 20 74 68 65 |d papule|s on the|
|00003770| 20 66 61 63 65 20 61 6e | 64 0d 0a 6c 65 73 69 6f | face an|d..lesio|
|00003780| 6e 73 20 66 75 72 74 68 | 65 72 20 63 6c 61 73 73 |ns furth|er class|
|00003790| 69 66 69 65 64 20 61 73 | 20 61 63 74 69 76 65 20 |ified as| active |
|000037a0| 6f 72 20 6c 65 73 73 20 | 61 63 74 69 76 65 2e 20 |or less |active. |
|000037b0| 20 4d 61 63 75 6c 65 73 | 20 28 72 65 73 6f 6c 76 | Macules| (resolv|
|000037c0| 69 6e 67 0d 0a 6c 65 73 | 69 6f 6e 73 29 20 77 65 |ing..les|ions) we|
|000037d0| 72 65 20 61 6c 73 6f 20 | 6e 6f 74 65 64 2e 0d 0a |re also |noted...|
|000037e0| 20 20 20 20 20 54 68 69 | 72 74 79 2d 66 6f 75 72 | Thi|rty-four|
|000037f0| 20 70 61 74 69 65 6e 74 | 73 20 63 6f 6d 70 6c 65 | patient|s comple|
|00003800| 74 65 64 20 74 68 65 20 | 73 74 75 64 79 3b 20 31 |ted the |study; 1|
|00003810| 35 20 72 65 63 65 69 76 | 65 64 20 64 6f 78 79 63 |5 receiv|ed doxyc|
|00003820| 79 63 6c 69 6e 65 20 61 | 6e 64 20 31 39 0d 0a 72 |ycline a|nd 19..r|
|00003830| 65 63 65 69 76 65 64 20 | 6d 69 6e 6f 63 79 63 6c |eceived |minocycl|
|00003840| 69 6e 65 2e 20 20 54 72 | 65 61 74 6d 65 6e 74 20 |ine. Tr|eatment |
|00003850| 77 61 73 20 67 6f 6f 64 | 20 6f 72 20 65 78 63 65 |was good| or exce|
|00003860| 6c 6c 65 6e 74 20 69 6e | 20 37 33 25 20 6f 66 0d |llent in| 73% of.|
|00003870| 0a 64 6f 78 79 63 79 63 | 6c 69 6e 65 2d 74 72 65 |.doxycyc|line-tre|
|00003880| 61 74 65 64 20 70 61 74 | 69 65 6e 74 73 20 61 6e |ated pat|ients an|
|00003890| 64 20 69 6e 20 38 34 25 | 20 6f 66 20 6d 69 6e 6f |d in 84%| of mino|
|000038a0| 63 79 63 6c 69 6e 65 2d | 74 72 65 61 74 65 64 20 |cycline-|treated |
|000038b0| 70 61 74 69 65 6e 74 73 | 3b 20 74 68 65 0d 0a 64 |patients|; the..d|
|000038c0| 69 66 66 65 72 65 6e 63 | 65 20 77 61 73 20 6e 6f |ifferenc|e was no|
|000038d0| 74 20 73 69 67 6e 69 66 | 69 63 61 6e 74 2e 20 20 |t signif|icant. |
|000038e0| 54 6f 6c 65 72 61 6e 63 | 65 20 77 61 73 20 65 78 |Toleranc|e was ex|
|000038f0| 63 65 6c 6c 65 6e 74 20 | 69 6e 20 35 33 25 20 6f |cellent |in 53% o|
|00003900| 66 20 70 61 74 69 65 6e | 74 73 20 69 6e 0d 0a 74 |f patien|ts in..t|
|00003910| 68 65 20 64 6f 78 79 63 | 79 63 6c 69 6e 65 20 67 |he doxyc|ycline g|
|00003920| 72 6f 75 70 20 61 6e 64 | 20 33 37 25 20 6f 66 20 |roup and| 37% of |
|00003930| 70 61 74 69 65 6e 74 73 | 20 69 6e 20 74 68 65 20 |patients| in the |
|00003940| 6d 69 6e 6f 63 79 63 6c | 69 6e 65 20 67 72 6f 75 |minocycl|ine grou|
|00003950| 70 2e 20 20 53 69 64 65 | 0d 0a 65 66 66 65 63 74 |p. Side|..effect|
|00003960| 73 20 77 65 72 65 20 6d | 69 6e 69 6d 61 6c 20 69 |s were m|inimal i|
|00003970| 6e 20 62 6f 74 68 20 67 | 72 6f 75 70 73 2e 0d 0a |n both g|roups...|
|00003980| 20 20 20 20 20 44 6f 78 | 79 63 79 63 6c 69 6e 65 | Dox|ycycline|
|00003990| 20 61 6e 64 20 6d 69 6e | 6f 63 79 63 6c 69 6e 65 | and min|ocycline|
|000039a0| 20 61 72 65 20 65 71 75 | 61 6c 6c 79 20 65 66 66 | are equ|ally eff|
|000039b0| 65 63 74 69 76 65 20 69 | 6e 20 74 68 65 20 74 72 |ective i|n the tr|
|000039c0| 65 61 74 6d 65 6e 74 20 | 6f 66 20 61 63 6e 65 0d |eatment |of acne.|
|000039d0| 0a 76 75 6c 67 61 72 69 | 73 2c 20 62 75 74 20 64 |.vulgari|s, but d|
|000039e0| 6f 78 79 63 79 63 6c 69 | 6e 65 20 68 61 73 20 74 |oxycycli|ne has t|
|000039f0| 68 65 20 61 64 76 61 6e | 74 61 67 65 20 6f 66 20 |he advan|tage of |
|00003a00| 61 20 6f 6e 63 65 2d 64 | 61 69 6c 79 20 72 65 67 |a once-d|aily reg|
|00003a10| 69 6d 65 6e 2e 0d 0a 44 | 6f 78 79 63 79 63 6c 69 |imen...D|oxycycli|
|00003a20| 6e 65 2c 20 35 30 20 6d | 67 20 6f 6e 63 65 20 64 |ne, 50 m|g once d|
|00003a30| 61 69 6c 79 2c 20 69 73 | 20 72 65 63 6f 6d 6d 65 |aily, is| recomme|
|00003a40| 6e 64 65 64 20 66 6f 72 | 20 74 68 65 20 74 72 65 |nded for| the tre|
|00003a50| 61 74 6d 65 6e 74 20 6f | 66 20 61 63 6e 65 2e 0d |atment o|f acne..|
|00003a60| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00003a70| 0a 0d 0a 20 20 20 20 20 | 44 6f 78 79 63 79 63 6c |... |Doxycycl|
|00003a80| 69 6e 65 20 69 73 20 77 | 69 64 65 6c 79 20 70 72 |ine is w|idely pr|
|00003a90| 6f 6d 6f 74 65 64 20 61 | 62 72 6f 61 64 20 61 73 |omoted a|broad as|
|00003aa0| 20 62 65 69 6e 67 20 65 | 66 66 65 63 74 69 76 65 | being e|ffective|
|00003ab0| 20 66 6f 72 20 61 63 6e | 65 20 69 6e 20 61 0d 0a | for acn|e in a..|
|00003ac0| 64 6f 73 61 67 65 20 6f | 66 20 35 30 20 6d 67 20 |dosage o|f 50 mg |
|00003ad0| 64 61 69 6c 79 2e 20 20 | 49 6e 20 74 68 69 73 20 |daily. |In this |
|00003ae0| 73 74 75 64 79 2c 20 35 | 30 20 6d 67 20 6f 66 20 |study, 5|0 mg of |
|00003af0| 64 6f 78 79 63 79 63 6c | 69 6e 65 20 64 61 69 6c |doxycycl|ine dail|
|00003b00| 79 20 77 61 73 20 66 6f | 75 6e 64 20 74 6f 0d 0a |y was fo|und to..|
|00003b10| 62 65 20 6f 6e 6c 79 20 | 73 6c 69 67 68 74 6c 79 |be only |slightly|
|00003b20| 20 6c 65 73 73 20 65 66 | 66 65 63 74 69 76 65 20 | less ef|fective |
|00003b30| 74 68 61 6e 20 31 30 30 | 20 6d 67 20 6f 66 20 6d |than 100| mg of m|
|00003b40| 69 6e 6f 63 79 63 6c 69 | 6e 65 20 64 61 69 6c 79 |inocycli|ne daily|
|00003b50| 2e 20 20 54 68 65 20 61 | 75 74 68 6f 72 0d 0a 64 |. The a|uthor..d|
|00003b60| 6f 65 73 20 6e 6f 74 20 | 74 72 79 20 74 6f 20 65 |oes not |try to e|
|00003b70| 78 70 6c 61 69 6e 20 6f | 72 20 65 76 65 6e 20 73 |xplain o|r even s|
|00003b80| 70 65 63 75 6c 61 74 65 | 20 75 70 6f 6e 20 74 68 |peculate| upon th|
|00003b90| 65 73 65 20 73 75 72 70 | 72 69 73 69 6e 67 20 72 |ese surp|rising r|
|00003ba0| 65 73 75 6c 74 73 2c 20 | 69 6e 20 74 68 61 74 0d |esults, |in that.|
|00003bb0| 0a 64 6f 78 79 63 79 63 | 6c 69 6e 65 20 61 6e 64 |.doxycyc|line and|
|00003bc0| 20 6d 69 6e 6f 63 79 63 | 6c 69 6e 65 20 61 72 65 | minocyc|line are|
|00003bd0| 20 73 6f 20 76 65 72 79 | 20 73 69 6d 69 6c 61 72 | so very| similar|
|00003be0| 20 74 6f 20 6f 6e 65 20 | 61 6e 6f 74 68 65 72 20 | to one |another |
|00003bf0| 69 6e 20 74 68 65 69 72 | 0d 0a 67 61 73 74 72 6f |in their|..gastro|
|00003c00| 69 6e 74 65 73 74 69 6e | 61 6c 20 61 62 73 6f 72 |intestin|al absor|
|00003c10| 70 74 69 6f 6e 2c 20 62 | 69 6f 61 76 61 69 6c 61 |ption, b|ioavaila|
|00003c20| 62 69 6c 69 74 79 2c 20 | 73 65 72 75 6d 20 68 61 |bility, |serum ha|
|00003c30| 6c 66 2d 6c 69 66 65 2c | 20 65 78 63 72 65 74 69 |lf-life,| excreti|
|00003c40| 6f 6e 0d 0a 70 61 74 74 | 65 72 6e 2c 20 65 74 63 |on..patt|ern, etc|
|00003c50| 2e 2d 2d 50 2e 45 2e 20 | 50 6f 63 68 69 2c 20 4d |.--P.E. |Pochi, M|
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|00003c70| 59 52 42 30 34 37 35 35 | 7d 0d 0a 24 54 69 74 6c |YRB04755|}..$Titl|
|00003c80| 65 7b 54 68 65 20 41 6e | 74 69 62 69 6f 74 69 63 |e{The An|tibiotic|
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|00003ca0| 6f 66 20 50 72 6f 70 69 | 6f 6e 69 62 61 63 74 65 |of Propi|onibacte|
|00003cb0| 72 69 75 6d 20 61 63 6e | 65 3a 20 20 41 20 31 35 |rium acn|e: A 15|
|00003cc0| 2d 59 65 61 72 20 42 61 | 63 74 65 72 69 6f 6c 6f |-Year Ba|cteriolo|
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|00003d30| 61 74 69 6f 6e 7b 4b 61 | 6e 73 61 69 20 4d 65 64 |ation{Ka|nsai Med|
|00003d40| 20 55 6e 69 76 2c 20 4f | 73 61 6b 61 2c 20 4a 61 | Univ, O|saka, Ja|
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|00003e00| 0a 24 44 61 74 65 7b 41 | 70 72 69 6c 20 31 39 38 |.$Date{A|pril 198|
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|00003e80| 65 6e 74 61 74 6f 72 7b | 50 2e 45 2e 20 50 6f 63 |entator{|P.E. Poc|
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|00003ea0| 79 72 69 67 68 74 20 28 | 63 29 20 59 65 61 72 20 |yright (|c) Year |
|00003eb0| 42 6f 6f 6b 20 4d 65 64 | 69 63 61 6c 20 50 75 62 |Book Med|ical Pub|
|00003ec0| 6c 69 73 68 65 72 73 2c | 20 49 6e 63 2e 2c 20 31 |lishers,| Inc., 1|
|00003ed0| 39 38 39 0d 0a 0d 0a 31 | 39 38 39 20 59 65 61 72 |989....1|989 Year|
|00003ee0| 20 42 6f 6f 6b 20 6f 66 | 20 44 65 72 6d 61 74 6f | Book of| Dermato|
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|00003f00| 74 65 72 20 31 2d 2d 41 | 63 6e 65 20 61 6e 64 20 |ter 1--A|cne and |
|00003f10| 52 65 6c 61 74 65 64 20 | 44 69 73 6f 72 64 65 72 |Related |Disorder|
|00003f20| 73 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |s....---|--------|
|00003f30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f70| 2d 2d 2d 2d 2d 0d 0a 54 | 68 65 20 41 6e 74 69 62 |-----..T|he Antib|
|00003f80| 69 6f 74 69 63 20 53 75 | 73 63 65 70 74 69 62 69 |iotic Su|sceptibi|
|00003f90| 6c 69 74 79 20 6f 66 20 | 50 72 6f 70 69 6f 6e 69 |lity of |Propioni|
|00003fa0| 62 61 63 74 65 72 69 75 | 6d 20 61 63 6e 65 3a 20 |bacteriu|m acne: |
|00003fb0| 20 41 20 31 35 2d 59 65 | 61 72 0d 0a 42 61 63 74 | A 15-Ye|ar..Bact|
|00003fc0| 65 72 69 6f 6c 6f 67 69 | 63 61 6c 20 53 74 75 64 |eriologi|cal Stud|
|00003fd0| 79 20 61 6e 64 20 52 65 | 74 72 6f 73 70 65 63 74 |y and Re|trospect|
|00003fe0| 69 76 65 20 45 76 61 6c | 75 61 74 69 6f 6e 0d 0a |ive Eval|uation..|
|00003ff0| 0d 0a 4b 75 72 6f 6b 61 | 77 61 20 49 3b 20 4e 69 |..Kuroka|wa I; Ni|
|00004000| 73 68 69 6a 69 6d 61 20 | 53 3b 20 41 73 61 64 61 |shijima |S; Asada|
|00004010| 20 59 0d 0a 28 4b 61 6e | 73 61 69 20 4d 65 64 20 | Y..(Kan|sai Med |
|00004020| 55 6e 69 76 2c 20 4f 73 | 61 6b 61 2c 20 4a 61 70 |Univ, Os|aka, Jap|
|00004030| 61 6e 29 0d 0a 4a 20 44 | 65 72 6d 61 74 6f 6c 20 |an)..J D|ermatol |
|00004040| 31 35 3a 31 34 39 2d 31 | 35 34 2c 20 41 70 72 69 |15:149-1|54, Apri|
|00004050| 6c 20 31 39 38 38 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |l 1988..|--------|
|00004060| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004070| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004080| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004090| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000040a0| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 41 62 73 74 |--------|....Abst|
|000040b0| 72 61 63 74 0d 0a 0d 0a | 20 20 20 20 20 41 6e 74 |ract....| Ant|
|000040c0| 69 62 69 6f 74 69 63 20 | 74 68 65 72 61 70 79 2c |ibiotic |therapy,|
|000040d0| 20 62 6f 74 68 20 73 79 | 73 74 65 6d 69 63 20 61 | both sy|stemic a|
|000040e0| 6e 64 20 74 6f 70 69 63 | 61 6c 2c 20 66 6f 72 20 |nd topic|al, for |
|000040f0| 74 72 65 61 74 69 6e 67 | 20 61 63 6e 65 20 68 61 |treating| acne ha|
|00004100| 73 20 70 72 6f 76 65 64 | 0d 0a 74 6f 20 62 65 20 |s proved|..to be |
|00004110| 65 66 66 65 63 74 69 76 | 65 2c 20 62 75 74 20 72 |effectiv|e, but r|
|00004120| 65 73 69 73 74 61 6e 63 | 65 20 73 74 72 61 69 6e |esistanc|e strain|
|00004130| 73 20 6f 66 20 50 72 6f | 70 69 6f 6e 69 62 61 63 |s of Pro|pionibac|
|00004140| 74 65 72 69 75 6d 20 61 | 63 6e 65 73 20 68 61 76 |terium a|cnes hav|
|00004150| 65 20 72 65 63 65 6e 74 | 6c 79 0d 0a 62 65 65 6e |e recent|ly..been|
|00004160| 20 72 65 70 6f 72 74 65 | 64 20 61 66 74 65 72 20 | reporte|d after |
|00004170| 6c 6f 6e 67 2d 74 65 72 | 6d 20 75 73 65 2e 20 20 |long-ter|m use. |
|00004180| 54 68 65 20 61 63 74 75 | 61 6c 20 6d 69 6e 69 6d |The actu|al minim|
|00004190| 75 6d 20 69 6e 68 69 62 | 69 74 6f 72 79 20 63 6f |um inhib|itory co|
|000041a0| 6e 63 65 6e 74 72 61 74 | 69 6f 6e 73 0d 0a 28 4d |ncentrat|ions..(M|
|000041b0| 49 43 73 29 20 6f 66 20 | 39 20 61 6e 74 69 6d 69 |ICs) of |9 antimi|
|000041c0| 63 72 6f 62 69 61 6c 20 | 61 67 65 6e 74 73 20 61 |crobial |agents a|
|000041d0| 67 61 69 6e 73 74 20 50 | 2e 20 61 63 6e 65 73 20 |gainst P|. acnes |
|000041e0| 69 73 6f 6c 61 74 65 64 | 20 66 72 6f 6d 20 61 63 |isolated| from ac|
|000041f0| 6e 65 20 70 61 74 69 65 | 6e 74 73 0d 0a 77 65 72 |ne patie|nts..wer|
|00004200| 65 20 64 65 74 65 72 6d | 69 6e 65 64 20 61 6e 64 |e determ|ined and|
|00004210| 20 74 68 65 20 72 65 73 | 75 6c 74 73 20 77 65 72 | the res|ults wer|
|00004220| 65 20 63 6f 6d 70 61 72 | 65 64 20 77 69 74 68 20 |e compar|ed with |
|00004230| 4d 49 43 73 20 6f 66 20 | 6f 74 68 65 72 73 20 6f |MICs of |others o|
|00004240| 62 74 61 69 6e 65 64 20 | 69 6e 20 33 0d 0a 70 72 |btained |in 3..pr|
|00004250| 65 76 69 6f 75 73 20 73 | 74 75 64 69 65 73 20 61 |evious s|tudies a|
|00004260| 74 20 74 68 65 20 73 61 | 6d 65 20 63 65 6e 74 65 |t the sa|me cente|
|00004270| 72 20 69 6e 20 74 68 65 | 20 70 61 73 74 20 31 35 |r in the| past 15|
|00004280| 20 79 65 61 72 73 2e 0d | 0a 20 20 20 20 20 50 72 | years..|. Pr|
|00004290| 6f 70 69 6f 6e 69 62 61 | 63 74 65 72 69 75 6d 20 |opioniba|cterium |
|000042a0| 61 63 6e 65 73 20 73 74 | 72 61 69 6e 73 20 77 65 |acnes st|rains we|
|000042b0| 72 65 20 69 73 6f 6c 61 | 74 65 64 20 66 72 6f 6d |re isola|ted from|
|000042c0| 20 74 68 65 20 63 6f 6d | 65 64 6f 6e 65 73 20 6f | the com|edones o|
|000042d0| 66 20 34 36 0d 0a 70 61 | 74 69 65 6e 74 73 2e 20 |f 46..pa|tients. |
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|00004bb0| 2d 37 31 7d 0d 0a 24 44 | 61 74 65 7b 4d 61 72 63 |-71}..$D|ate{Marc|
|00004bc0| 68 20 31 39 38 38 7d 0d | 0a 24 59 42 56 6f 6c 7b |h 1988}.|.$YBVol{|
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|00004c60| 59 65 61 72 20 42 6f 6f | 6b 20 4d 65 64 69 63 61 |Year Boo|k Medica|
|00004c70| 6c 20 50 75 62 6c 69 73 | 68 65 72 73 2c 20 49 6e |l Publis|hers, In|
|00004c80| 63 2e 2c 20 31 39 38 39 | 0d 0a 0d 0a 31 39 38 39 |c., 1989|....1989|
|00004c90| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 44 65 | Year Bo|ok of De|
|00004ca0| 72 6d 61 74 6f 6c 6f 67 | 79 20 28 52 29 0d 0a 0d |rmatolog|y (R)...|
|00004cb0| 0a 43 68 61 70 74 65 72 | 20 31 2d 2d 41 63 6e 65 |.Chapter| 1--Acne|
|00004cc0| 20 61 6e 64 20 52 65 6c | 61 74 65 64 20 44 69 73 | and Rel|ated Dis|
|00004cd0| 6f 72 64 65 72 73 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |orders..|..------|
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|00004d30| 6d 70 61 72 69 73 6f 6e | 20 6f 66 20 44 61 70 73 |mparison| of Daps|
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|00004d50| 52 65 74 69 6e 6f 69 63 | 20 41 63 69 64 20 69 6e |Retinoic| Acid in|
|00004d60| 20 74 68 65 20 54 72 65 | 61 74 6d 65 6e 74 20 6f | the Tre|atment o|
|00004d70| 66 20 4e 6f 64 75 6c 61 | 72 0d 0a 43 79 73 74 69 |f Nodula|r..Cysti|
|00004d80| 63 20 41 63 6e 65 0d 0a | 0d 0a 50 72 65 6e 64 69 |c Acne..|..Prendi|
|00004d90| 76 69 6c 6c 65 20 4a 53 | 3b 20 4c 6f 67 61 6e 20 |ville JS|; Logan |
|00004da0| 52 41 3b 20 52 75 73 73 | 65 6c 6c 2d 4a 6f 6e 65 |RA; Russ|ell-Jone|
|00004db0| 73 20 52 0d 0a 28 45 61 | 6c 69 6e 67 20 48 6f 73 |s R..(Ea|ling Hos|
|00004dc0| 70 2c 20 53 6f 75 74 68 | 61 6c 6c 2c 20 45 6e 67 |p, South|all, Eng|
|00004dd0| 6c 61 6e 64 3b 20 53 74 | 20 4a 6f 68 6e 27 73 20 |land; St| John's |
|00004de0| 48 6f 73 70 20 66 6f 72 | 20 44 69 73 65 61 73 65 |Hosp for| Disease|
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|00004e00| 4c 6f 6e 64 6f 6e 29 0d | 0a 43 6c 69 6e 20 45 78 |London).|.Clin Ex|
|00004e10| 70 20 44 65 72 6d 61 74 | 6f 6c 20 31 33 3a 36 37 |p Dermat|ol 13:67|
|00004e20| 2d 37 31 2c 20 4d 61 72 | 63 68 20 31 39 38 38 0d |-71, Mar|ch 1988.|
|00004e30| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|00004e40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e80| 2d 0d 0a 0d 0a 41 62 73 | 74 72 61 63 74 0d 0a 0d |-....Abs|tract...|
|00004e90| 0a 20 20 20 20 20 44 61 | 70 73 6f 6e 65 2c 20 61 |. Da|psone, a|
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